Research reveals： Why do some people always look older than their actual age？
Every one of us will inevitably face aging.
Aging is a common and complicated process, and it is a process of gradual decline of physical and psychological functions. Previous studies have revealed that aging is the main risk factor of many diseases (such as cancer, heart disease and diabetes), so studying aging is the key to improve human health.
In recent years, scientists have conducted in-depth research on aging and found some important factors called "signs of aging". A new study called "Hallmarks of aging: an expanding universe" reveals the aging symbol The Secret Behind for us. The study was published in Cell Journal in 2023, and translated into Chinese as "Signs of Aging: An Expanding Universe".
Image source: Cell
This research is based on a comprehensive paper that integrates various research methods. Scientists have used various technical means from genomics to metabonomics to fully understand the mechanism of aging. They analyzed a large number of experimental data, including animal models and human samples, and integrated the research results from different fields.
The paper summarizes nine main signs of aging. These signs are the core factors in the process of aging, which is very important for us to understand the mechanism of aging.
-Genome stability: The degradation of DNA damage repair mechanism is an important sign of aging.
-Chromatin imbalance: Cell function and gene expression are affected by disordered chromatin structure.
-Metabolic dysfunction: Metabolic dysfunction may accelerate the aging process.
-Cell aging and death: the disorder of the internal mechanism of cells leads to cell aging and apoptosis.
-Damage accumulation: With the passage of time, various tissues of our body are inevitably damaged.
-Inhibition of aging: Our bodies have some mechanisms to resist the aging process.
-Environmental response and homeostasis: Environmental factors and cell stress response have a profound influence on aging.
-Intercellular communication disorder: Intercellular communication becomes more difficult, leading to tissue degradation.
-Organizational degeneration: the structure and function of different organizations are gradually out of balance.
Understanding the mechanism of aging is helpful for us to prevent and treat diseases related to aging. Researchers try to delay or even reverse the aging process through intervention research on these aging markers. For example, some drugs and interventions have achieved some encouraging results in the experimental stage.
In addition, in terms of genome stability, scientists have studied genes related to DNA repair and found that by enhancing the functions of these genes, the degree of DNA damage can be effectively reduced, thus delaying the aging process.
In terms of metabolic dysfunction, some studies show that by adjusting diet and exercise habits, metabolic function can be improved and the risk of metabolic-related diseases can be reduced. In addition, some new drug research and development are also exploring metabolic dysfunction, hoping to find more effective treatment. In addition, studies show that the process of cell aging and death can be delayed by some interventions. For example, scientists have found that some compounds can activate the self-repair mechanism in cells, thus prolonging the life of cells. This provides important clues for developing new strategies to treat aging.
In addition, some important findings have been made in the study of environmental response and steady state. Proper regulation of cell stress response and environmental factors can promote the recovery and stability of the body and slow down the aging speed. This has led researchers to make more in-depth research on the influence of environmental factors and lifestyle on aging in order to formulate more personalized anti-aging programs.
However, despite some encouraging progress, we are still in the journey of exploring aging. Aging is an extremely complicated process, which involves many interrelated factors. Therefore, it is necessary to further study the mechanism of aging and explore more innovative treatment methods.
Generally speaking, this paper presents us with a huge and complex aging "universe". Through in-depth research on all aspects of aging, we gradually understand the main factors of aging and have achieved some exciting research results.
These research results provide important clues for us to know and understand the mechanism of aging, and also provide new ideas for developing anti-aging interventions and treatments. However, aging is still a challenging field, which needs continuous efforts and in-depth research.
In the future, we look forward to seeing the efforts of more scientists, constantly revealing the essence of aging, and improving human health, so that we can enjoy a healthier and longer life in this endless years.
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reference data
[1] López-Otín C, Blasco MA, Partridge L, et al. Hallmarks of aging: An expanding universe. Cell. 2023 Jan 19; 186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3. PMID: 36599349.
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