Risk warning： The genetic risk of COVID-19 was found in the analysis of thousands of patients.

　　Risk warning: genetic risk alert: genomic analysis of methods of patients returns genetic risk factors for long covid was found in thousands of patients.

　　SARS-CoV-2 (green) particles (red) on infected kidney cells, COVID-19 virus.

　　Long COVID is a complex complication that scientific researchers have been paying attention to since the epidemic of new Covid virus. It is considered to be related to more than 200 symptoms, including extreme fatigue, neuralgia, attention and memory disorders. A recent genome-wide study reveals its genetic risk factors, which is expected to have a positive guidance for future research on such diseases.

　　This study, published in the preprint paper "Genome-wide Association Study of Long Covid" on medrxiv, collected data from 6450 patients with long new crowns from 16 countries. It was found that a DNA sequence near FOXP4 gene was related to the growth of new crown, and FOXP4 gene was active in lung and some immune cells. This research result provides a new perspective for us to understand the genetic risk factors of the long new crown and provide a larger research in the future.

　　Comprehensive analysis of 11 long COVID GWAS studies showed that FOXP4 loci were related.

　　GWAS and meta-analysis identifies 49 genetic variants underl

　　For more than three years, the global "COVID-19 Host Genetics Initiative" has been searching for DNA sequences related to the severe risk of COVID-19. And researchers have discovered genes involved in the immune system and helping Covid-19 enter cells. Geneticist Hugo Zeberg and his research team integrated data from 24 studies, nearly 6,500 patients with new crowns, and more than 1 million other subjects as control group. They found a specific region in the genome associated with a 0.6-fold increase in the risk of new crowns, which is close to the FOXP4 gene active in lungs and other organs. This variation related to the long new crown was also found to have a higher expression level in lung cells.

　　Expression of FOXP4 in lung

　　Zeberg and his colleagues found that although severe COVID-19 may increase the risk of new crown growth, the contribution of this DNA mutation to the risk of new crown growth is too great to be explained only by its association with severe COVID-19. They found that the effect of this mutation on the long new crown was much stronger than that on the severe disease in COVID-19.

　　With the emergence of new data and research methods, the association between FOXP4 gene and long crown can be evaluated more accurately, and then new treatment strategies can be explored. Although this study is only a preliminary result, it shows us how to use genome data to find genetic risk factors of complex diseases, paving the way for future research.

　　However, growing a new crown is an extremely complicated disease, and there is still much work to be done. Researcher Chris Ponting and his team hope to find more genetic risk factors by studying the DNA of 15,000 patients with long new crowns. Although their research application was rejected by the funding judges, Ponting insisted on the importance of this work. He said: "It is very complicated, but we must find out the reasons behind it. The long new crown has caused huge health and socio-economic costs. "

　　Although researchers face multiple challenges, this discovery is undoubtedly a breakthrough. New research may find more genetic risk factors and help us understand why some people suffer from new crowns, while others can fully recover from them. We look forward to more research in the future to reveal the genetic risk factors of long new crowns, and believe that through understanding these risk factors, we will be able to better prevent and treat this complex disease.